Endocrine Abstracts

Androgens play an important role in the development and the maintenance of the normal prostate gland. Androgen Receptor (AR) signaling is also critical during the initiation and development of prostate cancer that may present with a range of genomic lesions possibly due to DNA repair defects. We first noted a significant correspondence between DNA breakpoints and AR binding sites supporting the inter-related action that hormone regulation plays a role on genomic events. We hyp...